Types of drug eruption
The mechanisms whereby a drug can trigger urticariainclude IgE-mediated instant hypersensitivity, immunecomplex-mediated generation of activated complementcomponents (serum sickness), a direct action on mast cellscausing them to release histamine, and modulation ofarachidonic acid metabolism. The drugs generally implicatedin urticaria are:• Penicillin and relatedantibiotics• X-ray contrast media• Enzymes• Blood products• Opiates• Non-steroidal
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